1999 Pokemon Game 10/102 Mewtwo 1st Edition Shadowless Base Set Holo (PSA 5 EX) (PSA Number: 78752785). Often regarded as the smartest Pokemon. Mewtwo was created by a scientist after years of horrific gene splicing and DNA engineering experiments. Its DNA is actually almost the same as Mew's, but its body size is vastly different. Its cold, glowing eyes strike fear into its foes. Because its psychic abilities were raised to the ultimate level, it only thinks about defeating its enemies as it rests in an undiscovered cave. Even though it has a powerful body, scientists failed to give it a compassionate heart and it turned vicious as a result. It rests to conserve energy, so that it can unleash its full power in battle.