Time magazine cover, dated January 13, 1975, signed in blue felt tip ink by John Laragh. Minor creasing, otherwise, in very good condition. John Laragh is an outstanding clinician-scientist who discovered that renin, a mostly forgotten kidney hormone, causes essential hypertension1,2 and its complications.3 This discovery led to two new classes of drugs, angiotensin-converting enzyme inhibitors and angiotensin receptor blockers, which revolutionized the treatment of hypertension, cardiovascular disease, diabetes, and kidney disease and improved innumerable lives.This lot came from the Jim Wiggins collection we purchased in July 2022. Jim Wiggins accumulated the most unique and valuable autograph collection over a period of 70-plus years. He obtained his collection either in person or by writing to persons of fame and notoriety. Comes with a full Letter of Authenticity from Todd Mueller Authentics.