2021 Topps Big League Baseball is a trading card set that has a 300-card base set featuring veterans and rookies, along with subsets like "Big League Best," "Award Winners," and "Highlights". It features a "wax era" inspired design with parallels including Orange, Rainbow Foil, Black and White, Blue Foil, and Black Foil. The set also includes new inserts like "Souvenirs" and "Art of the Game," returning inserts such as "Defensive Wizards" and "Wanted," and autographed cards